* More than 8.5 million people have cancer. 
* There are reported to be 850,000 individuals with diagnosed and undiagnosed HIV infection or AIDS  and
* Based on 2001 data, there were 184,000 organ recipients  An even more extensive list of at-risk people includes the untold millions on drugs called corticosteroids. Prednisone®, Medrol®, and a variety of similar medications are given to both adults and children. These drugs are prescribed for dozens of conditions including asthma; allergies; eczema; emphysema; Crohn’s disease; multiple sclerosis; herniated spinal discs; acute muscular pain syndromes; and all types of rheumatoid and autoimmune diseases. As much as 60% of the entire population could be considered to be “chemically immunosuppressed.” It is important to realize that FluMist is CONTRAINDICATED for people who are immunocompromised. People who receive FluMist and are living with an immunocompromised person put their loved ones at risk. Will this make stores that administer the vaccineslike Walmart and the other pharmaceutical chain stores that have announced they will carry FluMist risky places to shop for large segments of the population? What measures will be taken in these stores to ensure that the virus will not become commingled with food? What hand washing policy is going to be enforced in the stores for all Walmart employees and customers who have received FluMist? These are reasonable questions that deserve answers. The target market for FluMist is “healthy children and adults, ages 5 to 49 yrs.” Some believe that by vaccinating these people, a type of “herd immunity” will occur that will protect the very young and the elderly who are excluded from getting this vaccine. However, it is these very “at-risk” populations who may suffer the most from the flu by being exposed to people who are given FluMist. According to information presented at the May, 2003 National Influenza Summit, approximately 85% of Americans between the ages of 20 and 50 go unvaccinated, and nearly 66% between the ages of 50 and 64 do not receive the flu vaccine. Have there been “raging epidemics” across the country due to lack of flu vaccinations? It appears that the massive campaign to vaccinate everyone this year appears may be motivated, in part, by economics. The viruses suspected to be the most likely cause for the flu this season were negligibly different from the strains used in last year’s flu vaccine. Therefore, the influenza vaccine produced for the 2003-2004 season is identical in composition to the one used last year. This marks only the second time that the same strains have been used during two consecutive flu seasons. Consider that antibodies from other viral vaccinessuch as MMR, polio and chickenpox vaccineslast at least 3 years, and in some instances, up to 15 years. If the viruses used in the vaccine are the same as last year, why is this year’s vaccine even necessary? An ever greater concern about FluMist is the contents within the vaccine. Each 0.5ml of the formula contains 10 6.5-7.5 particles of live, attenuated influenza virus. That means that between 10 million and 100 million viral particles will be forcefully injected into the nostrils when administered. The viral strain was developed by serial passage through “specific pathogen-free primary chick kidney cells” and then grown in “specific pathogen-free eggs.” That means that the culture media was free of pathogens that were specifically tested for, but not a culture that was necessarily “pathogen-free.” The risk that the vaccine may contain contaminant avian retroviruses still remains. In addition, a stabilizing buffer containing potassium phosphate, sucrose (table sugar) and nearly 0.5 mg of monosodium glutamate (MSG) is added to each dose.  One of the most troubling concerns over the injection of this “chemical soup” is the potential for the viruses to enter directly into the brain.. At the top of the nasal passages is a paper-thin bone called the cribriform plate. The olfactory nerves pass through this bone and line the nasal passages, carrying messenger molecules to the brain that are identified as “smells” familiar to us. The olfactory tract has long been recognized as a direct pathway to the brain. Intranasal injection of certain viruses has resulted in a serious brain infection called encephalitis, presumably by direct infection of the olfactory neurons that carried the viruses to the brain. Time will tell whether the live viruses in FluMist will become linked to cases of encephalitis. The pharmaceutical companies do not necessarily always do a reasonable job of considering the “down side” when they are pushing new drugs or new vaccines. FluMist has the potential for causing the worst, most severe flu epidemic seen in years. Parents tell their young children not to put things up their noses because they might cause them harm. It would be wise to consider that advice for adults. With all the risks involved, one should be extremely cautious about what one allows to be sprayed in one’s nose. REFERENCES 1. DowJones Business News. Sept. 12, 2003. FluMist Available In Pharmacies This Fall.
2. Washington Post. Nasal spray for flu to get big media launch. Sept. 10, 2003, pg. E01
3. Washington Post. Spray vaccine for flu wins FDA clearance. June 18, 2003. pg. A01.
4. Mohammed, Madjid. Influenza as a bioweapon. J.R.Soc.Med. 2003;96:345-346.
5. Adler, Neil. MedImmune awaits the $1 billion mark and a new flu drug. The Business Gazette. Feb. 7, 2003.
6. FluMist package insert.
7. Vesikari T., et al. A randomized, double-blind, placebo-controlledtrial of the safety, transmissibility and phenotypic stability of a live, attenuated, cold-adapted influenza virus vaccine (CAIV-T) in children attending day care. Presented at the 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, (Chicago, IL). 2001
8. ibid. (Chicago, IL). 2001
9. Zangwell, Kenneth. Cold-adapted, live attenuated intranasal influenza virus vaccine. The Pediatric Infectious Disease Journal 2003; 22(3):273-274.
10. Drug information.
11. Diepgen TL. Is the prevalence of atopic dermatitis increasing? In: Williams HC, ed. Atopic Dermatitis: The Epidemiology, Causes and Prevention of Atopic Eczema. New York: Cambridge Univ Pr; 2000:96-112.
12. National Cancer Institute. CanQues. Available at http://srab. cancer.gov/Prevalence/canques.html. Accessed January 3, 2002.
13. Joint United Nations Programme on HIV/AIDS. Epidemiological Fact Sheets on HIV and Sexually Transmitted Infections: United States. Available at http://www.unaids.org/ fact_sheets/index.html. Accessed January 14, 2002
14. United Network for Organ Sharing (UNOS). All Recipients: Age at Time of Transplant. Available at http://www.unos.org /. Accessed January 14, 2002.
15. Allan and Harold Rubin, MS, ABD, CRC. September 26, 2003. Vaccinations and the Elderly..
16. May 20-21, 2003, the National Influenza Summit. Chicago, IL..
18. FluMist package insert.
19. Knipe, David. M. Ed. Fields Virology. Philadelpthis: Lippincott, 4th ed. 2001. pg. 1057
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